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Abbreviations AED: antiepileptic drug CNS: central nervous system CoA: coenzyme A CPS: carbamyl phosphate synthase GABA: -aminobutyric acid NAGA: N -acetyl glutamic acid NMDA: N -methyl-D-aspartate PCT: palmityl carnitine transferase VHE: VPA-induced hyperammonaemic encephalopathy VHT: VPA-induced hepatotoxicity VPA: valproic acid

Partially purified rat IDE activity was significantly inhibited by at least 40% at 10 3 M of GSSG and by more than 90% at 10 2 M

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Regarding intended users of DHTs, most applications (91.2%) was patient-facing, with 15 trials (5.6%) targeting healthcare providers and 8 trials (3.0%) involving both user groups

2023;15:e42479