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Researchers investigate whether pathway integration across incretin and glucagon receptor signaling creates distinct biological patterns compared with single-receptor or dual-receptor research models

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- TRIUMPH-3: Weight management trial in adults with established cardiovascular disease

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Efficacy analyses were performed on two sets: the full analysis set, defined as all unique randomized patients grouped according to the treatment assigned at randomization, thereby following the intent-to-treat principle, and an on-treatment analysis, defined as all exposed patients while they were receiving treatment (that is, had received at least one dose in the previous 35 d), grouped according to the treatment that they received