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50 As is well known that the PI3K/AKT/mTOR signaling pathway plays a crucial role in regulating the autophagy process of GCs and oocytes

Fisher AB, Dodia C, Manevich Y, Chen JW, Feinstein SI

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doi: 10.1016/S1087-0792(98)90020-X 45 HardelandRPoeggelerB

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I dont know all of the inputs that go into this decision but I can tell you based on our data (which is national and in the tens of thousands) the drug is not easily available to patients across the country