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Adults were randomly assigned, 1:1:1:2, to once-daily 6 mg orforglipron, 12 mg orforglipron, 36 mg orforglipron or placebo for 72 weeks

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In clinical trials conducted using the once to weekly subcutaneous semaglutide injection, combined with lifestyle interventions, participants treated with semaglutide demonstrated greater reductions in body weight at least 15 percent of their baseline body weight compared to those who received a placebo

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