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We did not have a good idea of whether these unpleasant side effects are related or necessary for the weight-loss effects. To find out, the Monell team investigated the brain circuits that link feeling full after ingesting a meal to those causing food avoidance due to feeling nauseated

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The results showed that 6-thio-dG and its dimer form exhibited strong inhibitory effects, with a high degree of alignment between experimental data and computational predictions