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Under ad libitum feeding conditions, we found that heart, body, and heart/body weights and nonfasting tail blood glucose measurements were not affected by treatment assignment (Supplemental Figure 1

Practice is better

If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely

Hair, skin, and other non-GI effects Rapid weight loss from any mechanism can trigger telogen effluvium, a temporary increase in hair shedding that occurs when the body diverts resources away from hair follicle maintenance

Labs are not required, but they may give your provider a more complete view of your overall health

They shed pounds more steadily without their body reducing calorie expenditure as much as it normally does with calorie restriction