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doi:10.1016/S0014-2999(97)01033-9 48

To address heterogeneity, the population, intervention, comparison, outcome, and study design (PICOS) framework was utilized in setting up a search strategy (Table 1)

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Among the proposed mechanisms for these effects, the reduction of toxic metabolites from fatty acids, especially LCAC under ischemic conditions, increased glucose oxidation during reperfusion, and consequently the reduction of lactate and H+ ion accumulation, resulting in the inhibition of acidosis in myocardial cells during ischemia, as well as the inhibition of harmful effects of free radicals released during reperfusion, are more prominently noted

Thats why GLP-1s were originally developed specifically for managing Type 2 diabetes

This drug is contraindicated in patients with personal or family history of MTC or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)