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Just to round out that portion of the workout picture
Copper delivery to superoxide dismutase (SOD) represents another arm of its activity
Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)
NCT, National Clinical Trial identifier
Additionally, multiple studies show that cells with downregulated GPX4 expression are more sensitive to ferroptosis compared to control cells [65]