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There is a close relationship between IR/diabetes and MAFLD, the mechanisms by which IR promotes MAFLD include changes in rates of adipose tissue lipolysis and de novo lipogenesis, impaired mitochondrial fatty acid -oxidation (FAO), changes in fat distribution, and alterations in levels of adipokines and cytokines (Tilg et al., 2017
T2DM is associated with fluctuating hyperglycemia despite optimal medical treatment 8,9
Kluger, G
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The MC38 murine colorectal cancer cell line (RRID: CVCL_B288) was obtained from the NIH NCI DCTD tumor repository in 2018
Myocardial reduced (GSH) and oxidized glutathione (GSSG) levels were measured as described previously (26, 33)
