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OCT4 is a transcriptional factor involved in early embryogenesis and very much essential for maintenance of pluripotency of SCs.[35] NANOG is a transcription factor and is involved in self-renewal capacity of undifferentiated SCs and has the ability to form any cell type of three germ layers of human body.[36,37] The third pluripotency gene is sex-determining region SOX2 which is also a transcription factor and maintains self-renew capacity of undifferentiated SCs.[38] Clinical applications of stem cell Although the use of SC has immense medical benefits, their applications in many diseases are still in the research and clinical trial phase and further studies are required for its long-term use in clinical settings

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