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MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

In addition to motor symptoms, many individuals with Parkinson's experience non-motor symptoms such as depression, anxiety, and sleep disturbances, which can complicate treatment and management

doi: 10.3390/jcm9124017 90 TrumboPR

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Administration in Special Populations 7.1 Administration to Elderly Patients In older adults, age-related physiological changes may influence glutathione metabolism and clearance