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They may also have subclinical conditions that could be affected by metabolic changes

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Routine testing of vitamin B12 levels in metformin-treated patients should be considered. Because metformin often causes digestive tract upset, many patients are also put on a proton pump inhibitor (PPIs) such as esomeprazole ( Nexium ), lansoprazole ( Prevacid ) or omeprazole ( Prilosec )

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For cardiovascular applications, this steadier exposure might provide more stable vascular effects compared to once-daily peaks and troughs