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For individuals who have tried a GLP-1 based compound and seen diminishing returns, the third receptor offers a new avenue for progress

The two pharmaceutical leaders in this space Novo Nordisk and Eli Lilly have seen astonishing growth in sales of their GLP-1 drugs for diabetes and obesity and have struggled to keep up with demand even at premium prices

In Drug Discovery & Developments Pharma 50, Lilly closed FY2025 at $65.18 billion in revenue, up 44.7% year over year, the steepest growth on the list

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Scientific Background Retatrutide was developed within a wider scientific effort to study multi-receptor agonism in metabolic disease