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: Therapeutic peptides: Current applications and future directions

Hada, M

Besides its classical role in modulating the stress response, NRF2 can also control basic cellular functions such as cell proliferation and differentiation, mitochondrial function, and protein quality control (Sykiotis and Bohmann, 2008

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Knockout of one allele of QPRT recapitulates these effects and increases susceptibility to AKI compared with control mice, which could be prevented by augmenting NAD + metabolism with oral NAM supplementation