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The binding of leptin to its receptor (Ob-R) in type II TRCs, activates K ATP channels, hyperpolarizing the cell in response to sweet stimuli

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The GWAS was performed including covariates as described in equation 1 above, with the addition of five genetic principal components to account for fine-scale genetic ancestry, and indicator variables to account for variation in the genotyping platform

It spans approximately 1 to 2 months

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Holst, J.J