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doi: 10.4049/jimmunol.167.8.4686 55 TamamuraHFujisawaMHiramatsuKMizumotoMNakashimaHYamamotoNet al

A 2020 preclinical toxicity review found no serious toxicity in mice, rats, rabbits, or dogs at tested doses, but longterm human carcinogenicity or organtoxicity data are missing