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In clinical trials, up to 15 percent of patients taking the full dose had to discontinue treatment due to side effects, which can include nausea, vomiting, diarrhea, and abdominal pain

What unites them is the idea that smaller doses might preserve some of the behavioral or metabolic effects of GLP-1 therapy while reducing tradeoffs such as nausea, muscle loss, or excessive appetite suppression

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GLP-1 medications can be effective for weight management because of their appetite-suppressing effects, which may lead to meaningful weight loss over time