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Regarding drug dosage, the maximum clinical trial dose of GLP-1RAs (such as liraglutide) reported in T1D is 1.8 mg/day subcutaneous injection [6], which can to some extent mitigate the impact of severe gastrointestinal reactions on tolerability and treatment adherence

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Some predictions suggest retatrutide may surpass existing weight-loss medications in potency and may be a next-generation therapy

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10.1111/dom.13082 Diabetes Obes

Giustina and Veldhuis (Endocrine Reviews, 1998) characterised the nocturnal GH pulse architecture that later secretagogue work used as a reference point