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Important safety considerations include: Diabetic retinopathy complications : Patients with pre-existing diabetic retinopathy should be monitored closely, particularly during rapid improvement in glucose control Gallbladder disease : Semaglutide has been associated with an increased risk of cholelithiasis and cholecystitis Acute pancreatitis : Patients should seek immediate medical attention if they experience severe, persistent abdominal pain that may radiate to the back, often accompanied by vomiting Dehydration and acute kidney injury : The gastrointestinal effects may lead to dehydration, which can cause acute kidney injury

GLP-1 receptor agonists and SGLT-2 inhibitors are prescribed by some healthcare providers off-label for people with type 1 diabetes, but the ADA does not currently recommend them due to insufficient efficacy and safety data

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doi: 10.1007/s11892-022-01485-w 4 RochfordJJ

Wullschleger, S., Loewith, R