The decision to continue or discontinue should be made collaboratively between patient and clinician, weighing benefits against costs, side effects, and individual preferences, in accordance with current NICE guidance and local NHS commissioning arrangements
"15-20% average weight loss" - Brand-reported figure
Zepbounds Lilly Direct self-pay vials run roughly $499/month for most dose levels
Common side effects documented across GLP-1 clinical trials include nausea, vomiting, diarrhea, constipation, and injection-site reactions
Keep a 23 week symptom log before and during GLP-1 initiation, noting stool frequency, urgency, pain, and energy levels
The muscle preservation argument Weight loss from GLP-1 agonists typically includes 25 to 40% lean tissue loss