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Median participant age was 47 years, and all participants were overweight or obese

was named as nominee for Secretary of Health and Human Services

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Accordingly, the major translational gaps between experimental models and human disease include species-specific differences in acinar-cell physiology and calcium handling, the oversimplified nature of experimental triggers compared with the etiological heterogeneity of clinical pancreatitis, the absence of common human comorbid modifiers in many animal models, limited access to early human pancreatic tissue for direct mechanistic analysis, and the lack of integrated human datasets linking morphology, transcriptomics, proteomics, and functional mapping of organelle interactions

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The rate of carnitine excretion is not a useful indicator of carnitine status because it can vary with dietary carnitine intake and other physiologic parameters