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Prescribing then rebounded, with modest growth from September through November (+0.05 percentage points per month), followed by a more pronounced increase from December 2025 through February 2026 (+0.10 percentage points per month)

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Other drugs that can lower the seizure threshold include: Bupropion, including drugs that contain bupropion such as Auvelity (bupropion/dextromethorphan) Tramadol, including drugs that contain tramadol such as Ultracet (tramadol/acetaminophen) Tricyclic antidepressants Other cyclobenzaprine interactions In addition to drug-drug interactions, its always important to know if your medication interacts with certain foods, drinks, supplements, or medical conditions

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Luo Y, Chen D, Xing XL