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It usually involves redness, small bumps, sensitivity, and breakout-like activity

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Rahman I, Smith CA, Lawson MF, Harrison DJ, MacNee W: Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells

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In chondrocytes from mice with IL-1-induced osteoarthritis, decreased protein expression of GPX4 and SLC7A11 and lipid ROS accumulation were observed, which inhibited the expression of type II collagen in chondrocytes and affected bone and joint health