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Ipamorelin's GHSR-1a mechanism is additive to GHRH-pathway stimulation because the two receptor systems converge on different intracellular signaling pathways (Gs-cAMP for GHRHR, Gq-PKC and MAPK for GHSR-1a) and can both stimulate somatotroph GH release simultaneously

The financial and opportunity cost must be considered to assess whether it is in the best interests of the research community, considering associated risks of trial failure

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Coverage for off-label uses may be limited

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