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Mistake 4: not rotating injection sites Injecting in the same spot repeatedly can cause lipodystrophy, localized areas of fat tissue changes that affect medication absorption

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For example, one study used an ASO to target a hairpin structure in the 5 UTR region of the LDLR mRNA that was inhibitory to protein translation, which resulted in an increase of LDLR protein expression and LDL uptake in HEK293T cells [82]