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Dehydration: Severe gastrointestinal side effects can lead to dehydration and, in some cases, acute kidney injury

Human trial results were more modest

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Unlike earlier generation medications that activate only one or two pathways, Retatrutide engages the full spectrum of incretin and metabolic hormone signaling

At their core, however, glucagon-like peptide-1 receptor agonists 9 act to enhance the body's natural response to food by mimicking the GLP-1 hormone

From subcutaneous to oral: Subjects receiving 0.5mg subcutaneously once weekly can switch to 7mg or 14mg orally once daily