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Next, we will study pharmacokinetics and bioavailability in suitable in-vivo animal models and perform the necessary toxicological evaluations

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However, neuronal death in ALS is independent of caspase-3 activation, and inhibition of caspase-3 does not affect the percentage of neuronal loss (Re et al., 2014)

[DOI] [PubMed] [Google Scholar] 33.Merkus F.W., Verhoef J.C., Marttin E., Romeijn S.G., van der Kuy P.H., Hermens W.A., Schipper N.G