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Avoid or limit caffeine and alcohol, which are dehydrating and may worsen constipation despite the common myth that coffee stimulates bowel movements

Long-term use may be necessary for sustained weight management, especially for people with obesity or metabolic conditions

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At present, natalizumab, a humanized monoclonal antibody against the cell adhesion molecule 4-integrin, is advantageously used in the treatment of multiple sclerosis and Crohn's disease (24)

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