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doi: 10.1016/j.jaad.2006.06.017 57 MeletiMMooiWJCasparieMKvan der WaalI

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Together, these mechanisms show that mitochondrial zinc homeostasis is a dynamic, tightly regulated process integrating zinc transport, enzymatic metallation, redox control and metabolic sensing, forming the molecular foundation through which zinc supports mitochondrial structure and function

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Yet, the full effect of Metformin develops gradually