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We dont have a lot of human data on that in terms of fasting

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10.1136/bmj.292.6517.397 Br Med J (Clin Res Ed)

49 mtDNA point mutations and deletions increase exponentially with age, disrupt the assembly of the oxidative phosphorylation complex, reduce adenosine triphosphate (ATP) and increase electron leakage, and form a vicious cycle of ROS-damage-ROS

Common things that can negatively impact vitamin B12 absorption and transportation: Strict vegan diet Low stomach acid diet Pancreatic insufficiency Intrinsic factor antibodies Slow TCNs - Fortified foods with synthetic folic acid SIBO Celiac Disease Crohns Vitamin B12 Supplements Vitamin B12 dietary supplements are very common

doi: 10.1007/s12325-019-00915-8 62 HansenBBNuhohoSAliSNDang-TanTValentineWJMalkinSJPet al