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This approach, borrowed from tirzepatide trials, proved effective at improving tolerability

Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp

In fact, looking at the planned 17.5mg and 27.5mg daily maintenance oral doses, when compared to the 15mg and 30mg doses used in VENTURE Oral show very comparable discontinuation levels, vomiting, nausea, diarrhoea and constipation data to placebo

If more than 10 hours have passed since the scheduled dose, skip that dose and take the next dose at the regular time

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Cancer Res 65 : 14791488