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Regulatory approval varies by country

PMID: 22005198

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Natural history, and clinical relevance of CHE The global prevalence of CHE in patients with cirrhosis is estimated at 40.9%, with rates of 48.4% in South-East Asia, 38.2% in the Americas, 37.2% in Europe, and 36.5% in Western Pacific regions [11]

Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3