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Genetic therapy approaches for ornithine transcarbamylase deficiency

We proposed stimulation of the DTC as part of a neuromodulation-based rehabilitation strategy for several reasons

Choline and methionine act as methyl donors, and the stated rationale is supporting hepatic fatty acid oxidation, mitochondrial function and lipid transport

Mediratta V, Rana S, Rao A, Chander R

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However, glutathione typically has low bioavailability in the body, and, in the past, the best method of supplementation was IV