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Key factors that may influence the likelihood and severity of diarrhoea include: Dose level higher doses are associated with greater gastrointestinal burden Rate of dose escalation faster titration schedules tend to worsen tolerability Individual gut sensitivity those with pre-existing gastrointestinal conditions such as irritable bowel syndrome (IBS) or inflammatory bowel disease may warrant additional clinical caution, although direct evidence specific to retatrutide is not yet available
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Chemico-Biological Interactions 232 :3037
J., Finikarides, L., Afzal, I., Lentjes, M., Luben, R., & Forouhi, N
However, decisions regarding the continuation or cessation of semaglutide therapy should be made on a case-by-case basis, considering the individual patients health status and treatment goals