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World Obesity Federation, World Obesity Atlas 2023 Unsurprisingly, weight loss medications have captured innovators attention as potential solutions, however, the obesity market has a history of many false dawns, as drugs in the past failed to deliver meaningful efficacy while some had serious safety issues, e.g., Fen-Phen, which was eventually withdrawn from the market due to cardiac risks 3
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Its not just a macro signal
This is more physiologically appropriate and likely explains why the combination of PTD-DBM (upstream release) with valproic acid (downstream activation) produces synergistic rather than merely additive effects