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There is also a theoretical concern observed in rodent studies with GLP-1 agonists regarding thyroid C-cell changes, though this has not been confirmed in humans and is not established as a contraindication in UK GLP-1 receptor agonist prescribing information

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Many providers use both for significant joint issues

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Participation, however, is voluntary

These agents draw water into the bowel, softening stool and increasing bowel movement frequency