Tirzepatide demonstrates several advantages in day-to-day use
Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate
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Cruchaga, and N
At the end of the treatment period, patients from both groups showed significant reductions in both the neuropathy symptom score and neuropathy disability score, with no meaningful difference between the two groups
I would recommend not spending any money on these because I dont think theyre going to do anything meaningful, she says