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Increased blood pressure makes bruising and swelling more intense

Non-pharmacological interventions (weight loss 7-10%, Mediterranean diet, and physical activity) are represented as the therapeutic basis, together with pharmacological strategies under investigation or clinical use (THR- agonists, FGF-21 analogs, pan-PPAR modulators, GLP-1 RAs, GLP-1/GIP, SGLT-2 inhibitors, metformin, and statins)

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2 TRIUMPH-1 is the larger, longer trial that confirms those earlier results

Trained athletes may normally have sinus bradycardia due to increased vagal tone