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This is important because 5% body weight loss is the threshold at which clinically meaningful health improvements typically begin, including reduced blood pressure, improved cholesterol profiles, and better glycemic control

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In addition to the above findings, several studies have shown that GLP-1RA therapy results in larger proportions of patients achieving 5% and 10% body weight loss than with placebo (Table 1)

Akeros lead candidate, EFX , targets MASH (metabolic-associated steatohepatitis) and is the only therapy to show meaningful regression in liver damage from cirrhosis