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In particular, H 2 O 2 promotes actin cytoskeleton reorganisation and cell migration by directly oxidising actin and actin-binding proteins 116 , as well as activating numerous cell signalling pathways associated with re-epithelialisation

This policy shift increases the likelihood that clinicians will need to document comorbid indications such as type 2 diabetes or cardiovascular disease to justify continued prescribing under covered diagnoses

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