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Although the precise mechanisms responsible for the accelerated atherosclerosis are not fully understood, it has been shown that endothelial dysfunction is one of the earliest events in the development of atherosclerosis

Disrupted sleep affects hormones, appetite regulation, mood, immune function, and paradoxically, weight loss itself

Importantly, this relationship is bidirectional: progressive MASLD and MASH impair circadian regulation through hyperammonemia, astrocyte dysfunction, altered glutamatergic signaling within the SCN, neuroinflammation, endocrine dysregulation, and HE, thereby reinforcing sleepwake fragmentation and chronobiologic instability

Bansal, S., Burman, A

Research suggests that Rhodiola can improve attention, memory, and mood by modulating neurotransmitter activity, protecting neurons from oxidative stress, and enhancing mitochondrial function [141]

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