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Osteoclasts, responsible for bone resorption, drive bone destruction in RA, influenced by factors like receptor activator of nuclear factor kappa- ligand (RANKL), interleukin-1 beta (IL-1), interleukin-6 (IL-6), and TGF-

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Following this step, benzene-1,3,5-trithiol (BTT) was introduced to the modified peptide, enabling bicyclization through a second nucleophilic aromatic substitution

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