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Until now, semaglutide has been considered the newest and the most powerful weight loss medication, but now tirzepatide appears to produce even greater weight loss by stimulating two satiety hormone receptors instead of just one

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Muscle loss is more likely to occur later if calorie intake is very low, protein intake drops, or resistance training is absent

doi:10.2133/dmpk.DMPK-10-RV-094 131