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Graphical Abstract Access this article Similar content being viewed by others Data Availability The data supporting the findings of this study are available through the corresponding authors upon request

Central Nervous System Activation Beyond the digestive tract, GLP-1 receptors are also activated in certain areas of the brain involved in appetite and satiety signals

Vitamin D Dosing While on MK-677 The Endocrine Society's 2011 clinical practice guideline recommends 1,500 to 2,000 IU/day of vitamin D3 for general deficiency prevention in adults, with therapeutic doses of 6,000 to 10,000 IU/day to correct deficiency, followed by a maintenance dose of 1,500 to 2,000 IU/day

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The inhibitory effects of peripheral adminis- tration of peptide YY(336) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

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