What is maintenance dosing, and why consider it The maintenance phase in weight management and type 2 diabetes care is a stage when a patient has achieved clinically significant progress, including desired weight reduction and/or optimal blood sugar levels
Each additional receptor contributes a distinct metabolic effect
Choosing Between Semaglutide and Tirzepatide for Microdosing From a pharmacology standpoint, semaglutide is a pure GLP-1 receptor agonist , while tirzepatide is a dual GIP/GLP-1 agonist that activates both GIP and GLP-1 receptors.[2,4] That dual mechanism likely contributes to tirzepatides strong weight-loss results at full doses compared with semaglutide in head-to-head and indirect comparisons.[2,7] In the context of microdosing: Some clinicians and patients feel that microdosing tirzepatide provides robust appetite control even at relatively low doses, though this is based largely on real-world experience rather than large trials
The STEP-1 trial showed that once-weekly semaglutide led to a net 15% weight loss in non-diabetic, obese/overweight patients
Each of these drug classes has its own set of potential side effects and interaction risks
Neuropsychopharmacology 30:747757 Bolin BL, Alcorn JL III, Reynolds AR et al (2016) Human drug discrimination: A primer and methodological review
