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The present review addresses this knowledge gap by identifying three key context-dependent mechanisms governing the dual role of lactate: Metabolic enzyme expression patterns, pH homeostasis capacity and antioxidant defense capabilities

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revealed that adding atorvastatin (20 mg/day, P.O for 4 weeks) reduced plasma MDA while improving the functional capacity assessed via a 6-minute walk test in patients with chronic heart failure (CHD) [228]

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