There are several possible explanations, says Laffin
In addition to their role in insulin secretion, GLP-1R agonists can also contribute to weight management, decrease the potential for cardiovascular diseases and protect beta cells
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The underlying cause, slowed gut motility from receptor activation, produces similar constipation characteristics regardless of which receptors are targeted
Enrolment of female participants is capped at approximately 70% to ensure sufficient male representation, given that participants typically seeking enrolment in obesity trials have been disproportionately female
Additionally, some people worry about becoming dependent on these medications or want more control over their treatment plan