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The ATTAIN-1 trial tested orforglipron in 3,127 adults with obesity or overweight with a weight-related condition

Small sips of an electrolyte drink or even clear broth can provide hydration without causing the bloating that sometimes comes from drinking large amounts of water at once

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Strategies like ligand-mediated uptake or intestinal permeation enhancers can enhance gut absorption

These therapies should never be positioned as replacements for established antihypertensive agents such as ACE inhibitors, ARBs, or calcium channel blockers