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When semaglutide or tirzepatide activates these receptors, neurotransmitter systems including dopamine, serotonin, and GABA shift in response

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The absolute levels of syeA transcripts in treated aphids averaged 49% of the levels in the control aphids (Wilcoxon rank-sum test with continuity correction: W = 122, P = 0.0043), and syeA transcripts were reduced relative to total RNA (see Supplementary Dataset 9 at Figshare 17 )

it does not prove that any of them will safely extend human healthspan