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Decision Guidance Choose cagrilintide + tirzepatide when you want the strongest single-agent base (tirzepatide is FDA-approved and outperforms semaglutide head-to-head) plus amylin layering

Inspect before use if it's cloudy or has visible particles, discard it

Pregnancy should be confirmed or excluded before administration in women

These are all normal responses to a life-changing injury

However, regardless of the form, both require constant refrigeration after being reconstituted into a solution

The FDA's concerns cite peptide manufacturing risks: incompletely characterised active ingredient, peptide fragments, degradation products, and impurities that the immune system may recognise as foreign